Rabbit Secondary Antibodies
Cayman Chemical FOXP1CTerm RabbIt Monclo 100uL
A pyrimidine analog and nitrosourea alkylating agent inhibits the growth of U-251MG and EA285 glioma cells at 10 g/ml increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors at 30 mg/kg
Cayman Chemical IgGmouse RabbIt MoncLNal 100ug
Immunogen: Mouse IgG • Host: Rabbit • Species Reactivity: (+) Mouse • Cross Reactivity: (+) Goat IgG; (+) Mouse IgG1, IgG2a, IgG2b, IgG3; (-) Human, rat IgG; (-) Mouse IgA, IgE, IgM • Applications: ELISA, WB (non-reducing conditions)
Cayman Chemical eIF2aPhosphoSer51 RabbIt 100uL
A prodrug form of the KCC2 activator CLP 257 increases the mechanical paw withdrawal threshold in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats at 100 mg/kg restores stepping ability as well as increases body weight support and stride length in a mouse model of paralysis at 35 mg/kg
Cayman Chemical AMPKa1 RabbIt MoncLNal ntI
A mixture of ganglioside GD3 with variable fatty acyl chains induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential at 200 M expression in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro ganglioside GD3-deficient adult mice exhibit progressive loss of the NSC pool and impaired neurogenesis
Cayman Chemical CD1n-Term RabbIt Monclon 100uL
A CaMKK inhibitor (IC50s 120 and 40 ng/ml for CaMKKa and CaMKKB respectively) selective for CaMKKs over CaMKI CaMKII CaMKIV MLCK PKC PKA and p42 MAPK (IC50s ≥ 10000 ng/ml for all) inhibits phosphorylation of CaMKI and AMPK in chicken sperm in the presence of extracellular calcium as well as reduces chicken sperm motility decreases Npy and Agrp expression and cumulative food intake in mice at 20 M 0.5 L/hour i.c.v. increases cortical striatal and total infarct volume in a mouse model of MCAO-induced focal transient cerebral ischemia at 3 g/animal i.c.v.
ABclonal Technology 488 Rabbit anti-Human IgA1
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 488 Rabbit anti-Human ROR1
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia Alternative splicing results in multiple transcript variants encoding different isoforms
ABclonal Technology 647 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants
Cayman Chemical HIston H4CTerm RabbIt Mo 100ug
Immunogen: Peptide corresponding to the C-terminus of human histone H4 • Host: Rabbit • Species Reactivity: (+) Vertebrates • Cross Reactivity: (+) H4A independent of PTMs; (-) Other histone proteins • Applications: ELISA, ICC, multiplex-based assays, WB
ABclonal Technology TRAF6 Rabbit mAb
The protein encoded by this gene is a member of the TNF receptor-associated factor (TRAF) protein family mediating signal transduction from the TNF receptor superfamily and the Toll IL-1 family It contains a RING domain four zinc-finger motifs a coiled-coil region and a TRAF-C domain This protein transduces signals from receptors like CD40 TNFSF11 and IL-1 and interacts with kinases such as IRAK1 SRC and PKCzeta linking different signaling pathways It plays a key role in the NF-kappaB pathway by activating IkappaB kinase (IKK) in response to proinflammatory cytokines This process requires its interaction with ubiquitin conjugating enzymes UBE2N UBC13 and UBE2V1 Additionally it interacts with the TGF beta receptor complex for Smad-independent activation of JNK and p38 kinases playing a vital role in antiviral and immune responses
ABclonal Technology 647 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
Cayman Chemical CaveolIn1CTRm RabbIt Mo 100uL
An analytical reference standard that is structurally similar to known synthetic cannabinoids a potential metabolite of 5-fluoro MPP-PICA based on the published metabolism of 5-fluoro AMB-PICA intended for research and forensic applications
ABclonal Technology 488 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
Cayman Chemical CD79aCTerm RabbIt Monclo 100uL
A BET family protein inhibitor inhibits binding of BRD2 BRD3 and BRD4 to an acetylated histone H4 peptide in vitro decreases Myc levels in and inhibits proliferation of AML DLBCL and MM cells reduces tumor growth in AML DLBCL and MM mouse xenograft models reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
ABclonal Technology 647 Rabbit anti-Human CD72
Predicted to enable signaling receptor binding activity Predicted to be involved in cell adhesion Is integral component of plasma membrane